Studies have demonstrated that diabetes increases the accumulation of IL-10-positive regulatory T cells (Tregs) and transforming growth factor-β (TGF-β)-positive MDSCs in the spleen and tumors of mice but decreases the percentage of NK cells producing interferon gamma (IFN-γ) and production of natural cytotoxicity triggering receptor 1 (NCR1/NKp46), PRF, granzyme B (GZMB), CD107a, and interleukin (IL)-17. The gene discussed is IFNG; the disease is diabetes mellitus.