Breast cancer mice with Treg-specific SRC-3 knockout exhibit high resistance to tumors because SRC-3 knockout Tregs infiltrate breast tumors by activating the C-C motif chemokine ligand (CCL)-19/CCL21/CCR7 signaling axis and promote the entry and function of effector T and NK cells by enhancing the IFN-γ/CXCL9 signaling axis 125. This evidence concerns the gene NCOA3 and breast neoplasm.