DKN-01 is an IgG4 antibody that effectively and specifically neutralizes human and mouse DKK1, and DKN-01 treatment promotes the induction of the NK-activating cytokines IL-15 and IL-33, as well as enhances CD45 cell recruitment, which is important in reducing lung metastasis in a mouse model of 4T1 breast cancer 78. The gene discussed is DKK1; the disease is breast carcinoma.