In human and mouse breast cancer tumors, IL20RA is highly expressed, which activates the Janus kinase 1/signal transducer and activator of transcription 3/SRY-box containing gene 2 signaling pathway, thus leading to the increased expression of PD-L1 in tumors and decreased recruitment of anticancer lymphocytes, including CD8+ T and NK cells 152. The gene discussed is CD274; the disease is breast cancer.