KLRK1 and neoplasm: In DNA-damaged tumor cells, uric acid can activate the TGF-β-activated kinase (TAK1)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)/extracellular regulated protein kinase (ERK) signaling pathway, ultimately resulting in the upregulation of NKG2D ligands (MICA/B) and enhancement of antitumor immune responses 58.