STAT3 and urinary bladder neoplasm: In this study, we investigated the anticancer properties of the health supplement sesamin: (1) Sesamin prevents the formation of bladder tumors; (2) Sesamin inhibits MMP2 expression by modulating the lincRNA-p21/STAT3 signaling pathway, thereby reducing key mechanisms of distant metastasis in bladder tumors, including migration, invasion, and anoikis resistance; (3) We also confirmed that sesamin can be used as an adjuvant therapy to enhance the sensitivity of conventional chemotherapeutic drugs, potentially allowing for reduced clinical dosages and minimizing chemotherapy side effects.