In this study, we investigated the anticancer properties of the health supplement sesamin: (1) Sesamin prevents the formation of bladder tumors; (2) Sesamin inhibits MMP2 expression by modulating the lincRNA-p21/STAT3 signaling pathway, thereby reducing key mechanisms of distant metastasis in bladder tumors, including migration, invasion, and anoikis resistance; (3) We also confirmed that sesamin can be used as an adjuvant therapy to enhance the sensitivity of conventional chemotherapeutic drugs, potentially allowing for reduced clinical dosages and minimizing chemotherapy side effects. This evidence concerns the gene MMP2 and urinary bladder neoplasm.