In children and adolescents with T1DM using the MDI regimen, the use of regular insulin as postmeal portion of an increased (130% ICR) and split insulin dose provided lower late (3–6 hr) blood glucose AUC following mixed fat and protein meals compared to a similarly increased and split dose using fast-acting insulin as pre- and postmeal portions as well as to a 100% ICR dose given entirely before the meal. The gene discussed is INS; the disease is type 1 diabetes mellitus.