Sex-related differences in renal outcomes in T1D have been studied extensively in adults with variable results depending on the cohort and study era, with sex-hormone levels, kidney hemodynamics, adiponectin concentrations, oxidative stress, and water-electrolyte homeostasis postulated as potential reasons for differences in a risk for DKD development and progression; however, there are limited data investigating the sex-related differences in renal function trajectories in children and adolescents [39–41]. Here, ADIPOQ is linked to diabetic kidney disease.