Severe COVID-19 is characterized in many cases by a proinflammatory state [10], with a dysregulation of immune cell cytokine secretion as membrane-bound or soluble small molecular weight proteins, including tumor necrosis factor-α (TNF-α), granulocyte macrophage colony-stimulating factor, monocyte chemoattractant protein-1 and 3, interferon-γ (IFN-γ), and diverse interleukins such as interleukin (IL)-1β, IL-2, IL-7, and IL-10 [10–14]. This evidence concerns the gene TNF and COVID-19.