Shepardson et al. [45] demonstrated that IFN-I expression can modulate susceptibility to methicillin-resistant Staphylococcus aureus (MRSA) infection, with IFN-β reducing host susceptibility to MRSA infection while IFN-α increases susceptibility. This evidence concerns the gene IFNB1 and methicillin-resistant staphylococcus aureus infectious disease.