RARα plays a crucial role in the selective activation of pro-inflammatory and anti-inflammatory signals, the absence of Hmbs can cause acute intermittent porphyria, leading to abdominal pain, neuropsychiatric disorders, and neuropathy, and Cox7b plays an important role in normal development of the central nervous system in vertebrates [38, 39]. Here, RARA is linked to acute intermittent porphyria.