IFITM1 and infection: In male mice, there were 478 DEGs in the infection group (MT) compared with the control group (MC); 122 genes with upregulated expression, such as Ifitm1, Wfdc21, Wfdc17, and Adam8 (P  < 0.001); and 356 genes with downregulated expression, such as Tuba1b and Cox7b (P  < 0.001) (Figure 1(b)).