The levels of cGAS, STING, and NLRP3 were significantly upregulated in intervertebral disc degeneration (IDD) patients, and epigallocatechin gallate (EGCG) treatment could inhibit cell apoptosis by target cGAS/STING/NLRP3 [68, 69] (Figure 4). This evidence concerns the gene NLRP3 and intervertebral disk degenerative disorder.