RORA and neoplasm: The chromodomain of CDY is a reader of methylated H3K9 and H3K27 as well as methylated lysines in non-histone proteins.64–66 Methylated non-histone substrate, such as retinoic acid-related orphan nuclear receptor α (RORα), is recognized by chromodomain of DCAF1.58 Binding of DCAF1 to monomethylated RORα leads to RORα degradation and thus loss of tumor suppressive activity exerted by RORα.