SW2_152F selectively disrupts CBX2's association with chromatin and inhibits the proliferation of LNCaP_NED cells, a subtype of androgen receptor (AR) antagonist-resistant cells derived from the androgen-sensitive prostate cancer cell line LNCaP.81 Recently, using nucleosome-based time-resolved fluorescence resonance energy transfer (TR-FRET) screening, compound 1 and compound 2 were identified as moderately potent small-molecule inhibitors of CBX282 (Table 1). This evidence concerns the gene AR and Familial prostate cancer.