CDKN2A and prostate cancer: Analysis of chromatin immunoprecipitation (ChIP) indicated that MS37452 at the concentration of 250 μM for 2 hours effectively releases the transcriptional suppression of the target gene p16/CDKN2A in PC3 prostate cancer cells via disrupting the recruitment of CBX7 to the INK4A/ARF locus.75 In the crystal structure of the CBX7–MS37452 complex, the dimethoxybenzene and piperazine rings are bound in the aromatic cage of CBX7, supporting that MS37452 antagonizes methyllysine substrates (Fig. 2B).