Conversely, a significant difference between diabetes type in trends over time was observed for SBP z-score (interaction term –0.0251, 95% CI: 0.0105–0.0397), DBP z-score (interaction term –0.0216, 95% CI: 0.0085–0.0347), BMI z-score (interaction term –0.019, 95% CI: 0.0045–0.0336), WC (interaction term –0.2232, 95% CI 0.0339, 0.4125) and CRP (interaction term –0.0182, 95% CI: 0.0077–0.0287), indicating greater reductions over time in blood pressure and BMI z-scores in youth with T1D compared to T2D and an increase over time in CRP in T2D compared to T1D. The gene discussed is CRP; the disease is type 2 diabetes mellitus.