Besides, two patients carried heterozygous ABCC8 variants from their respectively unaffected fathers and accepted octreotide treatment, one having the variant (p.L580_S581insFASL) that Wang et al. [46] documented as a de novo variant in a cohort of diabetes, another one carrying the variant (p.S986⁣∗) that Moalla et al. [47] reported in a 19-year male with diabetes. Here, ABCC8 is linked to diabetes mellitus.