Of relevance to Alzheimer’s disease, the trans-Golgi network (TGN) and early/late endosomes are compatible locations for APP processing by BACE1 (Burgos et al., 2010; Tan and Gleeson, 2019) and perturbations in the membrane organization of endosomes and the Golgi apparatus have been proposed to be intimately associated with the dysregulation of APP processing and amyloid-β production (Fourriere and Gleeson, 2021; Toh and Gleeson, 2016) (Small and Petsko, 2020). This evidence concerns the gene APP and Alzheimer disease.