Indeed, fragmentation of the Golgi cisternae has been observed in post-mortem Alzheimer’s disease brains (Baloyannis, 2014), in Alzheimer’s mouse neuronal models carrying familial Alzheimer’s disease (FAD) mutations (i.e., APPswe/PSEN1∆E9) (Joshi et al., 2014; Haukedal et al., 2023), and in a transgenic mouse model bearing mutated human Tau (P301S model) (Anton-Fernandez et al., 2017b). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.