Herba Patriniae, the third herbal component of YYFZBJS, has demonstrated anti-tumor effects in colorectal and bladder cancers through the P5330, TGF-β-Smad2/3-E-cadherin 5, and MAPK signaling pathways 31, supporting its role as a tumor suppressor. This evidence concerns the gene TGFB1 and urinary bladder cancer.