CASP3 and neoplasm: Therefore, Western blot was applied to demonstrate that RBM39 knockdown markedly decreased the expression level of Bcl-2, which its downregulation promotes tumor apoptosis and increased the expression levels of cleaved caspase-3、Bax and cleavage of poly (ADP-ribose) polymerase (PARP), which their overexpression promotes tumor apoptosis compared with control groups.