In our previous researches, when exosomes carrying miR-371b-5p were cocultured with human myeloma cell line 143B, the FUT4 levels decreased compared to the control group 10, compared to osteoblasts (hFOB1.19), osteosarcoma cells (KHOS and U2OS) expressed higher levels of FUT4, and inhibiting FUT4 expression reduced the proliferation, invasion, and migration abilities of osteosarcoma cells 15. The gene discussed is FUT4; the disease is plasma cell myeloma.