The results revealed enrichment of pathways such as FGFR3(fibroblast growth factor receptor 3) mutant receptor activation, GRB2 events in EGFR signaling, PD-1 signaling, Signaling by FGFR3 point mutants in cancer, FRS-mediated FGFR1 signaling, Signaling by EGFR in Cancer, Downstream signaling of activated FGFR1, PERK regulates gene expression, MAP2K and MAPK activation, PI3K Cascade, Signaling by FGFR1, and Oncogenic MAPK signaling in the high-risk group (Figure S7). This evidence concerns the gene EIF2AK3 and cancer.