Furthermore, it was observed that MTX2 expression in LUAD varied in association with a patient's smoking behavior according statistical comparisons in supplementary Table S1 (Fig. 4A), specific cancer stages according to statistical comparisons in supplementary Table S2 (Fig. 4B), and an analysis of the TP53 mutation status in relation to MTX2 expression also revealed various levels according to statistical comparisons in supplementary Table S3 (Fig. 4C). The gene discussed is MTX2; the disease is cancer.