Moreover, DHA and EPA up-regulated the expression of Rab GTPases and t-SNAREs, which mediated the approaching and fusing process of GLUT4 vesicles with plasma membranes, and further promoted blood glucose transfer into skeletal muscle, suggesting that marine n-3 PUFAs mitigate hyperglycemia by advancing GLUT4 vesicle translocation. This evidence concerns the gene SLC2A4 and Hyperglycemia.