The expression of IFN-response genes, including IFN-regulatory factor (IRF)-3 and -7; protein kinase R (PKR); Mx1; and IFN-stimulated gene-15, -54, and -56, was statistically downregulated after GNU-2353 infection and unaffected after infection with VR-2332 and GNU-2377 at 24 hpi; however, the levels of certain transcripts, including PKR and Mx1, altered at 48 hpi. The gene discussed is EIF2AK2; the disease is infection.