Regression coefficients were determined by utilizing λ_min + 1 SE, leading to the identification of 11 variables with nonzero coefficients as diagnostic predictors for CM (Figure 2B): HIV status, extracranial fungal infection, neutrophil percentage, CSF protein concentration, CSF pressure, extracranial tuberculosis, age, ESR, albumin levels, lymphocyte count, and IIS. The gene discussed is ALB; the disease is fungal infectious disease.