In terms of bone metabolism, T2DM patientspresented increased blood phosphorus (P; 1.12 mM), carboxyterminal cross-linked telopeptideof type I collagen (ICTP; 0.78 ng/mL), procollagen type I N-terminal propeptide (P1NP; 38.30ng/mL), and 25(OH)D levels (16.61 μg/L) ( P < 0.05) and decreased bloodcalcium, N-terminal midfragment of osteocalcin (N-MID; 11.00 ng/ml), parathyroid hormone(PTH; 31.80 ng/mL), and β-CrossLaps of type I collagen-containing cross-linked C-telopeptide(β-CTX; 0.32 ng/mL) levels ( P < 0.05) compared with controls. The gene discussed is BGLAP; the disease is type 2 diabetes mellitus.