MATN1 is involved in the structuring of multiple molecular aggregates of the extracellular matrix of cartilage129, 130 and studies carried out in mice have shown that those MATN1 deficient individuals, when faced with mechanical challenges in the joints, have greater cartilage degeneration than normal individuals, suggesting that this gene could be a target in the prevention of degenerative diseases such as OA.131. The gene discussed is MATN1; the disease is neurodegenerative disease.