On the other hand, miR-BART1 can also regulate the AMPK/mTOR/HIF-1 pathway in a PTEN-independent manner by directly targeting the α1 catalytic subunit of AMPK (AMPKα1), promoting anomalous aerobic glycolysis and angiogenesis in nasopharyngeal carcinoma (NPC) cells [140]. Here, PRKAA1 is linked to nasopharyngeal carcinoma.