WNK2 and obesity due to melanocortin 4 receptor deficiency: Among them, the Mitogen-Activated Protein Kinase (MAPK) pathway plays dual roles by regulating both adipogenesis and inflammation (Bost et al. 2005; Lawan et al. 2018); AMP-Activated Protein Kinase (AMPK) Pathway that reduces obesity by inhibiting adipogenesis and promoting thermogenesis, particularly in BAT (Martinez de Morentin et al. 2014).