Among them, the Mitogen-Activated Protein Kinase (MAPK) pathway plays dual roles by regulating both adipogenesis and inflammation (Bost et al. 2005; Lawan et al. 2018); AMP-Activated Protein Kinase (AMPK) Pathway that reduces obesity by inhibiting adipogenesis and promoting thermogenesis, particularly in BAT (Martinez de Morentin et al. 2014). This evidence concerns the gene WNK2 and obesity disorder.