Hepatic miRNA let-7b-5p is a potential reason why TGF-βRII is pro-fibrotic, as let-7b-5p is much higher in MASLD patients when TGF-β signaling is enhanced, whereas let-7b-5p is reduced in TGF-βRII KO in hepatocytes (Zhao et al. 2022). The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatotic liver disease.