NEGR1 and major depressive disorder: The overlapped PTSD DEPs include downregulated GABAergic genes SLC32A1, NEGR1, and PACSIN1 (see Additional file 1: Fig. S4E,F), which we consider are high-confidence PTSD DEPs, especially NEGR1 which is also a risk gene for multiple psychiatric disorders including MDD [51] and SCZ [52].