Both the PTSD-PM-skyblue and PTSD-PM-red, and the MDD-PM-grey60 and MDD-PM-darkred, are also significantly enriched for proteins specific to the presynaptic compartment (Additional file 1: Fig. S7 and Additional file 6: Table S5) including LY6H, which regulates neurotransmitter trafficking [77]. This evidence concerns the gene LY6H and major depressive disorder.