CFTR and cystic fibrosis: More than 2000 pathogenic mutations have been reported to date in Cystic Fibrosis Transmembrane Regulator (CFTR) gene and this explains, at least partly, the clinical heterogeneity observed in people with Cystic Fibrosis (pwCF) and the atypical manifestations in CFTR-related disorders (CFTR-RD) [1].