Currently, Wang et al. [41] identified 49 independent genetic loci significantly associated with EOCRC risk, and Alkhateeb et al. [50] found recurring missense mutations in several genes (AXIN2, ALK, CDKN1A, MAP3K1, ROS1, EPCAM, KDM5A, and AURKA) in over 50% of Canadian samples in addition to previously known colorectal cancer-associated genetic variants. Here, AXIN2 is linked to colorectal cancer.