VMA22 and hypothyroidism: For example, oral mannose can be used for mannose-6 phosphate isomerase- (MPI-) CDG, galactose for phosphoglucomutase-1- (PGM1-) CDG to increase coagulation factors and decrease serum transaminase levels, liver transplantation in MPI-CDG and coiled-coil domain containing 115- (CCDC115-) CDG, bone marrow transplantation in phosphoglucomutase-3- (PGM3-) CDG and in further variants treatment of specific symptoms like pericarditis, hypothyroidism and hypoglycemia [20, 22].