COL2A1 and Legg-Calve-Perthes disease: The explanation given for the top suggestion (SMPD3) is: “This gene is associated with Legg-Perthes disease, a condition that affects the hip joint in children and can lead to short stature.” While it is true that, in principle, a hip disorder can lead to short stature, there is no discoverable link between SMPD3 and Legg-Perthes disease, and the disorder is primarily associated with Col2A1 (OMIM:150600  37 ).