Pathway enrichment results revealed that CRC susceptibility genes are principally enriched in genes (i) regulating immune-related biological processes such as Th1 and Th2 cell differentiation and intestinal immune network for IgA production, (ii) involved in encoding proteins in cellular structures such as the actin cytoskeleton and MHC protein complex, and (iii) modulating signaling pathways such as the Rho GTPases (Supplementary Table 6). Here, HLA-C is linked to colorectal carcinoma.