These TFs have been reported to be involved in cancer development and differentiation (EGR3, ELF3, ETV2, FOXL131, HOXC11, HOXC12, HOXD12, PPARA::RXRA, SOX10, SP2, SP4, SP8, TBX15, and TWIST1), immune response and modulation (HSF2, IRF1, IRF2, IRF7, IRF932, and SPI1), and metastasis and invasion (FOXP333, KLF9, and RORB). The gene discussed is SP4; the disease is cancer.