Consistent with the detectable activity of HDAC10 on histones, a genetic knockout of HDAC10 in non-small cell lung cancer (NSCLC) and melanoma cells augmented the acetylation of histone H3 at K9/K27 and the expression of the cell cycle regulator cyclin A in certain tumor cells [14, 15]. The gene discussed is HDAC10; the disease is melanoma.