As shown in Supplementary Fig. 7A, activation of TGF-β signaling (10 ng/ml recombinant mouse TGF-β1) in CF for 48 h induced significant changes in 22 secreted proteins in comparison to TGF-β signaling inhibition (10 μM TGF-β receptor inhibitor SB-431542) (Supplementary Data 1). Here, TGFB1 is linked to cystic fibrosis.