Similarly, OPG (Tnfrsf11b), a cytokine belonging to the tumor necrosis factor receptor family which was significantly enhanced in the miCF secretome (Table 1), was also shown to be elevated during the acute phase after MI50 and to predict adverse cardiovascular events in stable coronary artery disease (PEACE trial)51. Here, TNFRSF11B is linked to coronary artery disorder.