Deregulated Wnt signalling contributes to the development of several AML subtypes including normal karyotype [12], FLT3-mutant [13], del(5q)+ [14], myelodysplastic syndrome (MDS)-related [15], CBF-mutated [16], and PML-RARα+ [17]. The gene discussed is RARA; the disease is myelodysplastic syndrome.