To investigate the therapeutic effects of UM164 on B-ALL in vivo, we transplanted Nalm6 cells into Non-obese diabetic (NOD)/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt (NCG) mice (Fig. 7A). This evidence concerns the gene GPT and precursor B-cell acute lymphoblastic leukemia.