To further determine the mechanism by which DDX21 regulates NAT10 expression, we analyzed the expression level of NAT10 in CRC cells treated with trichostatin A (TSA), a broad-spectrum inhibitor of HDAC family deacetylases, and nicotinamide (NAM), an inhibitor of SIRT family deacetylases. The gene discussed is DDX21; the disease is colorectal carcinoma.