Seifert et al. reported that necroptosis promotes pancreatic cancer development, found that RIPK1 and RIPK3 were highly expressed in pancreatic ductal adenocarcinoma, and inhibition of RIPK1 or deletion of RIPK3 prevented pancreatic cancer progression in vivo [116]. This evidence concerns the gene RIPK3 and pancreatic ductal adenocarcinoma.