Conversely, KIAA1429 deficiency inhibited the expression of KDM5B, and PD-L1 with green fluorescence, and reversed YTHDF1 overexpression-mediated up-regulation of KDM5B and PD-L1 in HCC cells (supplementary Fig. 4A, B). The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.