To dissect how drivers of stemness coordinate TMZ sensitivity of GBM cells induced by TGFBR2, we queried the TGFBR2 promoter and identified several Oct4 and Sox2 binding sites within 1 kb of the translation start site (Fig. 2a, top panel and Supplementary Fig. 3). The gene discussed is TGFBR2; the disease is glioblastoma.