SOX2 and glioblastoma: We recently reported that the architectural transcription factor high mobility group protein A1 (HMGA1) plays a critical role in euchromatin formation and gene expression changes during the epigenetic reprogramming of GBM cells to a stem-like state.30 Assay for transposase-accessible chromatin with sequencing (ATAC-Seq) experiments show increased chromatin accessibility in regions overlapping exon 1 of TGFBR2 in GBM neurospheres expressing transgenic Sox2 and Oct4 compared to parental controls (Fig. 2d).