We found that AD pathology-related GO terms such as amyloid beta metabolic process, amyloid beta formation, amyloid precursor protein catabolic process, regulation of amyloid-beta formation, tau protein binding, amyloid precursor protein metabolic process, and negative regulation of amyloid-beta formation terms were uniquely upregulated in cluster- 6 AD astrocytes. This evidence concerns the gene APP and Alzheimer disease.