In a similar way, the downregulation of GADD45A, together with the activation of the TGFβ signaling pathway, has been observed in fibrotic livers of murine models, while GADD45A overexpression downregulates the expression of extracellular matrix proteins and may counteract hepatic fibrosis by inhibiting the TGF‐β/SMAD signaling pathway [70]. The gene discussed is TGFB1; the disease is fibrosis.