NPPB and cardiac hypertrophy: There was also an increase in the expression of cardiac hypertrophy molecular markers, including myosin heavy chain 7 (Myh7 or β-myosin heavy chain, β-Mhc), and natriuretic peptide B (Nppb or Bnp), in KO mice compared with WT animals, although Myh6 (α-Mhc) was not modified (Fig. 6F).