AKT1 and obesity due to melanocortin 4 receptor deficiency: Likewise, resveratrol exerts its anti-hypertrophic effect in the heart by activating AMPK and inhibiting AKT [78], while AMPK inactivation correlates with cardiac hypertrophy and remodeling in rodent models with obesity induced by high-fat or high-fructose diets [79, 80].