TARDBP and Motor neuron atrophy: After removing Dox from the diet, the mutant hTDP-43 NLS is turned on, leading in the rNLS8 mice to extensive TDP-43 pathology underlying motor neuron degeneration accompanied by a downregulation of mouse endogenous TDP-43 that leads to some TDP-43 loss of splicing function (Luan et al. 2025).