Conversely, TMEM106B, a locus associated with modifying FTLD-TDP risk (Van Deerlin et al. 2010), encodes TMEM106B fibrils that have been found as a major component of inclusions in FTLD-TDP cases; these fibrils are present in different FTLD-TDP patients as well as in a wide range of other neurodegenerative disorders, including LATE, synucleopathies, or tauopathies amongst others (Perneel et al. 2023), together with the ageing brain (Schweighauser et al. 2022). The gene discussed is TMEM106B; the disease is tauopathy.