All MPE% remained between 85% and 115% of the actual AUC irrespective of weight descriptor or formula for renal function used, except for 24-hour creatinine clearance [MPE% = −17.6% (95% CI, −45.8 to 10.6)] and CKD-EPI (creatinine-cystatin C) in patients with BMI ≥30.0 kg/m2 [MPE% = −17.8% (95% CI, −33.1 to −2.4)], and flat dose in patients with BMI 25.0–29.9 kg/m2 [MPE% = 23.9% (95% CI, 7.1–40.7)] (Table 2). This evidence concerns the gene CST3 and chronic kidney disease.