The same trend was seen for CKD-EPI (creatinine-cystatin C) with respectively overestimation of 0.4% in patients with BMI <25.0 kg/m2, and underestimation in 25.0–29.9 kg/m2 −7.0% and −17.8% in ≥30.0 kg/m2 (see Supplemental Digital Content 4, http://links.lww.com/TDM/A834). The gene discussed is CST3; the disease is chronic kidney disease.