The mechanism that accounts for this discrepancy remains elusive, but as vascular inhibition of NEP activity can influence neuropeptide levels in the heart and kidney (Bellis et al., 2020; Haynes et al., 2020; Bozkurt et al., 2023), it may indirectly influence inflammatory processes in the brain now that the interplay of CNS with peripheral organs is well recognized in the etiology of neurodegenerative disease (Saido, 2024). Here, NPS is linked to neurodegenerative disease.