HLA-DRB1 and multiple sclerosis: To illustrate, HLA-DQB1*06, a risk factor for multiple sclerosis (MS) [31], has strong positive correlations with many HLA alleles associated with pathogen adaptation, including HLA-DQB1*06:01 (a subtype of HLA-DQB1*06), HLA-DRB1*08:03 (r2=0.38; genetically linked), and HLA-DRB1*15:01 (r2=0.49; being the strongest genetic risk factor for MS [32]).