Additionally, studies suggest that endoplasmic reticulum stress is implicated in the progression of ccRCC, with the expression of DERL1, DERL3, and other members of the endoplasmic reticulum stress-related protein family being associated with the epithelial-mesenchymal transition in lung and bladder cancers [28–30]. The gene discussed is DERL3; the disease is urinary bladder carcinoma.