The results from the MTT assay indicated that the proliferation ability of ACHN and Caki-1 ccRCC cells was significantly enhanced in the DERL3 overexpression group (ov−DERL3) compared to the control group, while the proliferation ability of ccRCC cells in the sh-DERL3 group was significantly reduced (Fig 5D, E). This evidence concerns the gene DERL3 and nonpapillary renal cell carcinoma.