Noting that the sample size is relatively small and noting the heterogeneous treatment, we can conclude that these findings indicate significant changes over time in the TME of short-OS myeloma patients, specifically in the T cell compartment, with a decrease in overall T cells, an increase in immunosuppressive Treg cells, and a shift toward a more activated and exhausted phenotype in the CD8+ T cell compartment. Here, CD8A is linked to plasma cell myeloma.