Figure 3A shows the heat map of common differential mRNA expression changes in three people with diabetes before and after intensive insulin therapy. Among them, 774 genes were down-regulated, and 417 genes were up-regulated. The GO function indicated that the commonly differentially expressed mRNAs were mainly located in Cell, Cell Part, Intracellular Part, Intracellular Binding, and Cell Progress, among others (Figure 3B). The KEGG pathway was mainly enriched in metabolic pathways, pathways in cancer, spliceosome, ubiquitin-mediated proteolysis, and herpes simplex infection (Figure 3C). Here, INS is linked to herpes simplex infectious disease.