Excess ROS on the background of a deprivation of the antioxidant system and the factors of endogenous neuroprotection (HSP70 and HIF-1) leads to the desensitization of receptors (GABA, serotonin, glutamine), suppression of transporter proteins expression, and an increase in psycho-emotional disorders—lethargy, fear, anxiety, disorientation, aggressiveness, and irritability. The gene discussed is HIF1A; the disease is Anxiety.