Extensive studies have established that targeted ferroptosis-related signaling pathways markedly impede the progression of AMD through multi-facial mechanisms, such as the GSH-GPX4 pathway, the FSP1–CoQ10–NADH pathway, dihydroorotate dehydrogenase (DHODH)–dihydroubiquione (CoQH2) pathway and GTP cyclohydrolase1–tetrahydrobiopterin (GCH1-BH4) axis, etc. [110]. Here, DHODH is linked to age-related macular degeneration.